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Cardura: Doxazosin may be administered either in the morning or in the evening.
Hypertension: The full dosage range of doxazosin is 1 mg to 16 mg daily. It is recommended that therapy be initiated at 1 mg once daily for 1 or 2 weeks to minimize the potential for postural hypotension and/or syncope (see Precautions). The dosage may then be increased to 2 mg once daily for an additional 1 or 2 weeks. If necessary, the daily dosage should then be increased gradually at similar intervals to 4 mg, 8 mg, and 16 mg, as determined by patient response, to achieve the desired reduction in blood pressure. The usual dose is 2 mg to 4 mg once daily.
Benign Prostatic Hyperplasia: The recommended initial dosage of doxazosin is 1 mg once daily to minimize the potential for postural hypotension and/or syncope (see Precautions). Depending on the individual patient's urodynamics and BPH symptomatology, dosage may then be increased to 2 mg and thereafter to 4 mg and up to the maximum recommended dose of 8 mg. The recommended titration interval is 1 to 2 weeks. The usual recommended dose is 2 to 4 mg once daily.
Cardura XL: Hypertension and Benign Prostatic Hyperplasia: Doxazosin GITS can be taken with or without food.
The GITS tablets should be swallowed whole with a sufficient amount of liquid. Patients should not chew, divide or crush the tablets (see Information for Patients under Precautions).
The initial dose of doxazosin GITS is 4 mg once daily. Over 50% of patients with mild to moderate severity hypertension will be controlled on doxazosin GITS 4 mg once daily. The optimal effect of doxazosin may take up to 4 weeks. If necessary, the dosage may be increased following this period to 8 mg once daily according to patient response.
The maximum recommended dose is 8 mg once daily.
Use in Elderly: Normal adult dosage is recommended.
Use in Renally Impaired Patients: Doxazosin is not dialysable. Since the pharmacokinetics of doxazosin are unchanged in patients with renal insufficiency, and there is no evidence that doxazosin aggravates existing renal dysfunction, the usual dosages may be used in these patients.
Use in Hepatically Impaired Patients: See Precautions.
Use in Children: The safety and efficacy of doxazosin in children have not been established.
